Cisplatin half-life
Webcisplatin and decline in a biphasic manner with a terminal half-life of 36 to 47 days. Over a dose range of 40 to 140 mg cisplatin/m. given as a bolus injection or as infusions varying … WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has spread to other parts of the body. It is used with other drugs in patients who have already had surgery ...
Cisplatin half-life
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WebCisplatin 1. NAME 1.1 Substance 1.2 Group 1.3 Synonyms 1.4 Identification Numbers 1.4.1 CAS 1.4.2 Other Numbers 1.5 Brand Names, Trade Names 1.6 Manufacturers, … WebPlasma concentrations of the parent compound, cisplatin, decay monoexponentially with a half-life of about 20 to 30 minutes following bolus administrations of 50 or 100 mg/m 2 …
WebPlasma concentrations of the parent compound, cisplatin, decay monoexponentially with a half-life of about 20 to 30 minutes following bolus administrations of 50 or 100 mg/m 2 doses. Monoexponential decay and … WebIntravenous carboplatin is rapidly cleared by the kidneys, with a 2.5 h half-life. It is exclusively eliminated by the kidneys, and is excreted in the urine essentially unchanged. Current indications. Carboplatin is used for most of the same solid cancer types as is cisplatin, including testicular, ovarian, lung, and head/neck. It is less often ...
WebMar 2, 2005 · The half-lives for total platinum and active drug were calculated by dividing 0.693 by the terminal rate constant. RESULTS Model-independent plasma ultrafiltrate and CSF pharmacokinetic variables for oxaliplatin, cisplatin and … WebAfter administration of 100 mg/m2 of cisplatin, maximum platinum levels in rbcs ranged from 0.51 to 0.58 micrograms/ml and were reached within 90-150 mins. Thereafter, rbc platinum levels declined in a biphasic fashion, with a terminal half-life, for the interval Days 5-15, of 36-47 days. The binding of platinum to both plasma and proteins and ...
WebUse in Cancer. Cisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with …
WebNov 2, 2024 · Platinum-based chemotherapy can be effective in treating many different types of cancer. For example, cisplatin is one of the most effective drugs for ovarian cancer with as many as 80% of people ... olympic staffing loginWebfrom 50 to 100 mg/m2, plasma cisplatin half-life is approximately 30 minutes. The ratios of cisplatin to total, free (ultrafilterable) platinum in the plasma range from 0.4 to 1.1 after a dose of 100 mg/m2. Cisplatin does not undergo instantaneous and reversible binding to plasma proteins characteristic of normal drug-protein binding. olympic staffing monroviaWebSep 7, 2024 · A We can calculate the half-life of the reaction using Equation 14.5.3: t 1 / 2 = 0.693 k = 0.693 1.5 × 10 − 3 m i n − 1 = 4.6 × 10 2 m i n Thus it takes almost 8 h for half of the cisplatin to hydrolyze. B After 5 half-lives (about 38 h), the remaining concentration of cisplatin will be as follows: 0.053 M 2 5 = 0.053 M 32 = 0.0017 M olympic staffing in ealing broadwayolympic staffing servicesWebDec 1, 1987 · Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the … olympic stain 716 cedar naturaltoneWebIn addition, the plasma elimination half-life of cisplatin is prolonged in renal failure. Caution should be exercised in patients with pre-existing renal dysfunction. Cisplatin is contraindicated in patients with serum creatinine levels greater than 0.2 mmol/L. Repeat courses are not advised until serum creatinine is below 0.14 mmol/L and/or ... olympic stadium in athensWebSep 6, 2024 · Plasma concentrations of the parent compound, cisplatin, decay monoexponentially with a half-life of about 20 to 30 minutes following bolus administration of 50 or 100 mg/m2 doses. Monoexponential decay and plasma half-lives of about 0.5 hour are also seen following two hour or seven hour infusions of 100 mg/m2. olympic stadiums after the games