Cisplatin mitochondria

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August undefined, 2024

WebJul 7, 2014 · A mitochondria-targeted Pt(IV)-prodrug of cisplatin, Platin-M, was designed by introducing two mitochondria-targeting delocalized lipophilic TPP cations in the axial positions (Fig. 1A). Recently, a Pt(II) … WebThe cellular uptake of cisplatin and its targets. Reprinted with permission. 1 As seen in Figure 1, once inside the cell, cisplatin has a number of possible targets: DNA; RNA; sulfur-containing enzymes such as metallothionein and glutathione; and mitochondria.

Astrocytes rescue neuronal health after cisplatin …

WebOct 13, 2024 · Cisplatin also disrupts mitochondrial biogenesis, as indicated by reduced renal expression of the master regulator of mitochondrial biogenesis PPARG coactivator 1 alpha (PPARGC1A, also known... WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as … curiosity consignment ashland city tn

Evaluation of mitochondria in mouse oocytes following …

WebMay 7, 2024 · Meanwhile, cisplatin causes nuclear and mitochondrial DNA damage, which activates peroxisome proliferator-activated receptor-γ coactivator-1α and increases transcription factor A (TFAM) expression. TFAM transposition to the mitochondria leads to mitochondrial biosynthesis and activation, thereby increasing mitochondrial ROS and … WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as ovarian, colorectal, prostate, lung, and... WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … curiosity consignment md

C-Jun N-terminal kinase signalling pathway in response to cisplatin

Roles of DNA damage in renal tubular epithelial cells injury

WebCisplatin is a platinum-based chemotherapeutic agent that induces peripheral neuropathy in 30% of patients. Peripheral neuropathy is the dose limiting side effect, which has no preventative therapy. We have previously shown that cisplatin induces apoptosis in dorsal root ganglion (DRG) sensory neuro … WebMitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. The resultant cisplatin-induced mitochondrial dysfunction may lead to a novel mechanism of cisplatin neurotoxicity. easy grits and shrimp recipeWebThe additive effects of metformin on cisplatin-induced inhibition of cell proliferation were attenuated under hypoxic conditions, while metformin compromised mitochondrial structure and function. Additional studies are needed to determine the efficacy of this drug combination in vivo. Publication types Research Support, Non-U.S. Gov't MeSH terms easy grip pens for adults

"WebApr 11, 2024 · Introduction. Ovarian cancer (OC) is a lethal gynecological malignancy. Most OC patients benefit from initial treatments with cytoreductive surgery followed by cisplatin (CP)-based chemotherapy 1.However, approximately 70% of OC patients relapse and develop drug-resistance after long-term use of CP 2.Multilayer alterations have been … " - Cisplatin mitochondria

Cisplatin mitochondria

Detouring of cisplatin to access mitochondrial genome …

Web2 days ago · Complex 37 and, above all, 38, were the most effective, but the latter led to higher activated Pt content inside the cells (probably because of its greater reduction rate), as well as inside the mitochondria, compared with complex 37 and cisplatin. To explore the mitochondrial effect caused by complexes 37 and 38, the level of mitochondria ... WebJun 30, 2024 · The novel aspect of our work suggested that cisplatin not only induces mitochondrial oxidative damage by attacking DNA and proteins in cancer cells, but also restrain mitochondria self-renewal by inhibiting mitochondrial fission and mitophagy, which lead to damaged mitochondrial accumulation.

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WebNational Center for Biotechnology Information WebAug 6, 2015 · The foremost reason of cisplatin-related cytotoxicity has been correlated to the generation of mitochondrial reactive oxygen species (ROS) that influence multiple …

WebNational Center for Biotechnology Information WebFunctional validation using SSBP1 knockdown demonstrated that the gene plays an important role in regulating mitochondrial mass. Depletion of SSBP1 increases the sensitivity of tumor cells to cisplatin-induced cell death, but only modestly impacts the ability of tumor cells to proliferate in the absence of the drug.

WebThe aim of this study was to determine the role of retrograde signaling (mitochondria to nucleus) in MCF7 breast cancer cells. Therefore, in the present study, MCF7-H and MCF7-J cybrids were produced using the mitochondria from the same H and J individuals that were already used in our non-diseased retinal pigment epithelium (ARPE19) cybrids. MCF7 … WebNov 19, 2013 · Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is …

WebJul 14, 2024 · Here we have extended this strategy by coordinating in the axial positions of kiteplatin ( [PtCl₂ ( cis -1,4-DACH)], DACH = Diaminocyclohexane) and its CBDCA (1,1-cyclobutanedicarboxylate) analogue the antioxidant α-Lipoic acid (ALA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK).

WebFeb 11, 2015 · cisplatin mitochondria imaging Supporting Information Details of chemical synthesis, structural analysis, and biological assays. This material is available free of … curiosity consignment warehouse boone ncWebJun 10, 2024 · NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell … curiosity consultingWebJul 1, 2024 · Background: Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. curiosity containersWebApr 23, 2024 · Cisplatin / toxicity Drugs, Chinese Herbal / therapeutic use* Humans Hyperalgesia / chemically induced Hyperalgesia / drug therapy Membrane Potential, Mitochondrial / drug effects Mice Neurotoxicity Syndromes Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Drugs, Chinese Herbal curiosity compassionWebmaintaining mitochondrial number and function is dem-onstrated by studies showing that the maturation of oo-cytes is severely impaired when mitochondrial activities are sub-optimal [26, 27]. Cisplatin is known to damage the DNA of oocytes, but the possibility that cisplatin also compromises oocyte survival and quality by damaging mitochondria ... curiosity consignment shop boone ncWebAug 30, 2024 · Both cisplatin and IFT88-KD caused primary cilia shortening, downregulated mitochondrial oxidative phosphorylation capacity, and had defective fatty acid oxidation and decreased ATP production. Furthermore, IFT88 overexpression enhanced mitochondrial respiration, which partially counteracted cisplatin-induced defective fatty … easy grocery tote sew easy grocery tote pattern