WebJan 7, 2016 · Lysophosphatidic acid (LPA) is an efficient, bioactive phospholipid involved in various biological processes. In this study, LPA-induced connective tissue growth factor (CTGF/CCN2) expression … WebJun 1, 2011 · The effect of LPA on the secretion of CTGF and PGF 2α from endometrial tissue was altered depending on different stages of endometrosis ( P < 0.05). ... Connective tissue growth factor (CTGF/CCN2 ...
(PDF) Expression of CTGF/CCN2 in response to LPA is …
WebApr 1, 2024 · Effect of lysophosphatidic acid (LPA) on fibrotic growth factor expression in the small airway epithelial basal cells (SAE BC). Primary SAE BC from each of 3 non-smoking individuals were plated in triplicate in the presence or absence of 1.0 μg/ml LPA and evaluated for expression of connective tissue growth factor (CTGF), endothelin-1 … WebJun 11, 2024 · These two processes can be affected by connective tissue growth factor (CTGF/CCN2) a highly regulated growth factor/cytokine which has been shown to be responsible for the induction of many fibrotic effects. ... These results strongly indicate that although LPA requires the presence of Smad-2/3 in order to induce CTGF, LPA has no … highland lakes trail map
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WebJan 19, 2024 · (CTGF/CCN2) is a pleiotropic protein with strong profibrotic activity. In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of Webeton were identified as critical determinants of CTGF expression induced by LPA and 5-HT, and also by TGF-b. Connective tissue growth factor (CTGF)1 belongs to the fam-ily of low affinity insulin-like growth factor binding proteins, which consists of Mac25, the nov oncogenes, and cyr61 (1), and is also classified as a member of the CCN (CYR61 ... WebActivation of LPA1 on mesothelial cells induced these cells to express connective tissue growth factor (CTGF), driving fibroblast proliferation in a paracrine fashion. ... therefore … highland lakes tiny homes kingsland tx