On-target effect
Web30 de jul. de 2024 · Kosicki et al. 2 caution that extensive on-target damage, especially damage involving translocations, may activate one of hundreds of dormant oncogenes in … Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependen…
On-target effect
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Web11 de set. de 2013 · On-target side effects refer to the pharmacodynamic effect on normal tissues that occurs when the target that's being inhibited in the tumor is also being inhibited in the normal tissue. Common on-target side effects include skin rash from … Web11 de abr. de 2024 · Thus, the Bonn researchers highlight the additive effect of NAE1 inhibition by MLN4924 in combination with cisplatin as a new treatment option for testicular cancer.
WebOn Target? generator This program is currently in development - see our forum for details Generate your own SCORM compliant interactive Flash learning games Play an example … WebCommon molecular target effect or on target effect includes amplified and unwanted in vivo responses originated from the targeted molecular site. Such effect is a mechanism-dependent adverse effect because of the interaction of a drug molecule in a receptor that generates intended biological action.
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