Phkg2 ferroptosis

Author: vmsk

August undefined, 2024

Webb5 apr. 2024 · Ferroptosis-related gene is an iron-dependent regulatory tumor cell death, driven by the lethal accumulation of lipid peroxidation . Previous literature reported that … Webb1 jan. 2024 · Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc − (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells.

PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori …

Webb31 aug. 2024 · A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma A ferroptosis-related gene signature was constructed to predict OS probability in LUSC. This could facilitate novel therapeutic methods and guide individualized therapy. Webb2 dec. 2024 · Ferroptosis is a newly discovered type of programmed cell death that, in an iron-dependent manner, peroxidizes unsaturated phospholipids and results in the … east coast bias in sports

WP_FERROPTOSIS - GSEA MSigDB

Webb30 apr. 2024 · Ferroptosis is an iron-dependent form of regulated cell death, which is driven by the lethal accumulation of lipid peroxidation ( 8 ). It is a novel death phenotype … Webb24 maj 2024 · Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key … WebbNational Center for Biotechnology Information east coast bicycle companies

The Molecular Mechanisms of Regulating Oxidative Stress

Webb3 feb. 2024 · Ferroptosis is a newly identified iron-dependent cell death that is different from other cell death forms, including apoptosis and necrosis. The program involves three primary metabolisms... Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non … cube meter to mlWebbCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer … east coast believers church live stream

"Webbför 2 dagar sedan · In this study, we assume that deep learning model learns the nonlinear interaction between molecular environment (expression profile of ferroptosis regulators) and ferroptosis regulation score (potential regulation level of ferroptosis), so as to make accurate prediction. " - Phkg2 ferroptosis

Phkg2 ferroptosis

A ferroptosis-related gene signature for overall survival prediction ...

WebbFerroptosis is a novel type of cell death in hepatic IRI that involves small molecules that inhibit glutathione biosynthesis or glutathione peroxidase 4 (GPX4), which is a glutathione‑dependent antioxidant enzyme, causing mitochondrial damage. WebbAlthough some publications investigated the correlations between ferroptosis and LUAD, [10] [11][12][13] this study aimed to explore multi-omics data on LUAD including mRNA expression, protein ...

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Webb20 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a better understanding of the unique pathogenesis of H. pylori-induced GC and allow for maximum efficacy of genetic, cellular, and immune therapies for controlling ferroptosis …

WebbFerroptosis, a newly discovered iron-dependent form of cell death, contributes to various pathologies; however, the prognostic value of ferroptosis-related genes (FRGs) in cervical cancer (CC) remains unclear. Herein, we identified 15 differentially expressed FRGs based on data from The Cancer Genome Atlas database. WebbPHKG2 is a key regulator of tumor development and immunotherapy response in H. pylori- related GC. • PHKG2 facilitates RSL3-induced ferroptosis in H. pylori positive GC cells by promoting ALOX5 expression. • These findings may contribute to a better understanding of the unique pathogenesis of H. pylori- induced GC. Abstract

Webb9 aug. 2024 · In this study, we constructed a 15-gene prognostic signature predicting overall survival based on ferroptosis-related genes (ferroptosis driver genes VDAC2, … WebbWe identified PHKG2 as a crucial regulator of ferroptosis in H. pylori-positive GC. Its expression is correlated with patient survival and ICI therapeutic response. …

Webb30 juli 2024 · Ferroptosis is characterized by iron accumulation, excessive production of ROS, and lipid peroxidation. This illustration shows the process of ferroptosis, summarizing the key molecules and targets regulating iron and lipid peroxidation.

Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. ... proteomic sequencing analysis and OP-B administration showed the up-regulation of AURKA and down-regulation of PHKG2 and SLC7A5 in the 12-gene signature, indicating that OP-B induced NSCLC ferroptosis. Determination of malondialdehyde (MDA), … cube mathlinkWebbFerroptosis, a novel type of programmed cell death, is different from the traditional cell death pathways such as ... which can oxidize PUFA by phosphorylating enzyme kinase G2 (PHKG2) -dependent iron pools through the diallyl site . Afterwards, AA-PE and AdA-PE catalyzed by LPCAT3 are oxidized by ALOX15 to generate LPO, leading to ... cube meter to cube feetWebb7 juni 2024 · Background: Ferroptosis, a regulated cell death which is driven by the iron-dependent peroxidation of lipids, plays an important role in cancer. However, studies about ferroptosis-related Long non-coding RNAs (lncRNAs) in breast cancer (BC) are limited. Besides, the prognostic role of ferroptosis-related lncRNAs and their relationship to … cube mettey bartWebbferroptosis inducers inhibit GPX4 by covalently targeting the active site selenocysteine, leading to accumulation of PUFA hydroperox-ides. In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 cube messe berlinWebb5 nov. 2024 · PHKG2 is a regulator of polyunsaturated fatty acid peroxidation during ferroptosis, and silencing PHKG2 attenuates U-2-OS cell sensitivity to Erastin. 18 HSD17B11 is an enzyme involved in reduction or oxidation of sex hormones and is reported to be enriched in RSL3-resistant cells. 19 STEAP3, a metalloreductase capable of … east coast biasWebb29 mars 2024 · PHKG2, IREB2, and CISD1 play an important role in ferroptosis by their function in iron metabolism balance. The phosphorylation of HSP27 induces ferroptosis resistance through blocking cytoskeleton-mediated iron absorption. EGLN1 can upregulate LSH expression by limiting HIF 1α. east coast bicycle tourWebb21 mars 2024 · PHKG2 (Phosphorylase Kinase Catalytic Subunit Gamma 2) is a Protein Coding gene. Diseases associated with PHKG2 include Glycogen Storage Disease Ixc … cube method program