WebApr 1, 2024 · TLM (left), 3-acetyl thiotetronic acid lead (middle), and predicted docking pose (right) of 3-acetyl thiotetronic acid in a complex with C171Q KasA enzyme (Protein data bank (PDB): 4c6u). WebMay 15, 2006 · Thiolactomycin (TLM, Fig. 1) is an antibacterial natural product with broad-spectrum activity originally isolated from a species of Nocardia. 1 The thiotetronic acid core structure and 5-position isoprene side chain of TLM are found in several other natural products including thiotetromycin, U68204, and 834-B1. 2 Thiotetronic acids inhibit fatty …
α‐Thiotetronic Acids, II. Reactions of γ‐Alkylidene‐α‐Thiotetronic ...
WebAcylation of (3H,5H)-tetrahydrothiophene-2,4-dione (thiotetronic acid) with acetyl, propionyl, and valeryl chlorides followed by O-C isomerization in the presence of 4-dimethylaminopyridine or acetone cyanohydrin gave rise to 3-acetyl, 3-propanoyl, and 3-pentanoyl derivatives of thiotetronic acid.The reaction of 3-acylthiotetronic acids with … WebWe show the production of a group of unusual thiotetronic acid natural products, including the well-known fatty acid synthase inhibitor thiolactomycin that was first described over 30 years ago, yet never at the genetic level in regards to biosynthesis and autoresistance. This finding not only validates the target-directed genome mining ... jean prouve biography
Studies on Tenuazonic Acid Analogs. III. Syntheses and Antitumor ...
WebThiotetronic acid 98%; CAS Number: 51338-33-1; Synonyms: 2,4-Tetrahydrothiophenedione,4-Hydroxy-2(5H)-thiophenone; find Sigma-Aldrich-340227 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. IN EN. Applications Products Services Support. All Photos (1) 340227. Web10: Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS. Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol. 2015 Dec 18;10(12):2841-2849. doi: 10.1021/acschembio.5b00658. Epub 2015 Oct 21. WebApr 25, 1976 · Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others April 1976 Yakugaku zasshi journal of the … jean pryor obituary