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Thiotetronic acid

WebApr 1, 2024 · TLM (left), 3-acetyl thiotetronic acid lead (middle), and predicted docking pose (right) of 3-acetyl thiotetronic acid in a complex with C171Q KasA enzyme (Protein data bank (PDB): 4c6u). WebMay 15, 2006 · Thiolactomycin (TLM, Fig. 1) is an antibacterial natural product with broad-spectrum activity originally isolated from a species of Nocardia. 1 The thiotetronic acid core structure and 5-position isoprene side chain of TLM are found in several other natural products including thiotetromycin, U68204, and 834-B1. 2 Thiotetronic acids inhibit fatty …

α‐Thiotetronic Acids, II. Reactions of γ‐Alkylidene‐α‐Thiotetronic ...

WebAcylation of (3H,5H)-tetrahydrothiophene-2,4-dione (thiotetronic acid) with acetyl, propionyl, and valeryl chlorides followed by O-C isomerization in the presence of 4-dimethylaminopyridine or acetone cyanohydrin gave rise to 3-acetyl, 3-propanoyl, and 3-pentanoyl derivatives of thiotetronic acid.The reaction of 3-acylthiotetronic acids with … WebWe show the production of a group of unusual thiotetronic acid natural products, including the well-known fatty acid synthase inhibitor thiolactomycin that was first described over 30 years ago, yet never at the genetic level in regards to biosynthesis and autoresistance. This finding not only validates the target-directed genome mining ... jean prouve biography https://theipcshop.com

Studies on Tenuazonic Acid Analogs. III. Syntheses and Antitumor ...

WebThiotetronic acid 98%; CAS Number: 51338-33-1; Synonyms: 2,4-Tetrahydrothiophenedione,4-Hydroxy-2(5H)-thiophenone; find Sigma-Aldrich-340227 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. IN EN. Applications Products Services Support. All Photos (1) 340227. Web10: Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS. Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol. 2015 Dec 18;10(12):2841-2849. doi: 10.1021/acschembio.5b00658. Epub 2015 Oct 21. WebApr 25, 1976 · Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others April 1976 Yakugaku zasshi journal of the … jean pryor obituary

Detection, Identification, and Occurrence of Thiotetronic …

Category:Thiotetronic acid Structure - C4H4O2S - Over 100 million chemical ...

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Thiotetronic acid

Evaluation of Antioxidant Properties of Monoaromatic Derivatives …

WebOct 22, 2001 · Acetyl thiotetronic acid analogues were prepared according to Scheme 1 and are shown in Table 1, Table 2.The acetyl thiotetronic acid 3 10 was condensed with aryl … WebJan 1, 2024 · Discovery of thiotetronic acid antibiotics. (A) The tlm BGC was prioritized by searching through the Salinispora pan-genome for duplicated housekeeping genes for BGCs as depicted. First, the core OGs present in all Salinispora were identified and grouped by similarity (i). Any duplicated OGs from the core genome were then examined (ii), and ...

Thiotetronic acid

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WebWe would like to show you a description here but the site won’t allow us. WebThe 3-unsubstituted thiotetronic acid 33 is 100% enolic in [2 H 6]dimethyl sulfoxide and exists completely as the keto tautomer 41 in [2 H]chloroform.Ozonolysis of the thioether …

WebThe UV absorption properties of several other pairs of thiotetronic acid ethers confirm that these differences are general features that provide a simple method for distinguishing between 2- and 4-substituted isomers. AB - O-Alkylation of thiotetronic acids gives a mixture of 2- and 4-position enol ether products. Comparison of the physical ... WebApr 25, 1976 · Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others April 1976 Yakugaku zasshi journal of the Pharmaceutical Society of Japan 96(4 ...

WebNational Center for Biotechnology Information WebOct 12, 2015 · Using this improved TAR, two thiotetronic acid BGCs were proficiently and directly cloned with an efficiency of 20-75% and expressed heterologously in a model …

WebOct 5, 2015 · This paper demonstrates that electrospray ionization (ESI) with differential ion mobility spectroscopy (FAIMS) and “soft” mass spectrometry (MS) provide unique analytical capabilities that led to the discovery of sulfur-containing polar congeners of thiotetronic acid (TA) in drinking water from underground sources in Canada and the United States. Polar …

WebIdentification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. Tang X, Li J, Millan-Aguinaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS ACS Chem Biol. 2015 Oct 21. PubMed Article Plasmids from Article. ID Plasmid Purpose ... jean prouve g star rawWebThe antibiotic contains a thiotetronic acid in the molecule and possesses a selective activity against Bacteroides fragilis. A new antibiotic, thiotetromycin, has been isolated from the … laburtzapenakWebOct 24, 1995 · The α-thiotetronic acid 1 reacts with amines predominantly with ring opening to give polyfunctionalized ketones (2) which readily cyclize to α-tetramic acid amides (4a, b).The reaction of α-thiotetronate 6 with nucleophiles is more complex, leading to either an open-chain derivative (8) or formation of an α-thiotetronic acid amide (3b) or an α … laburtuWebNational Center for Biotechnology Information jean psgWebSep 4, 2015 · Detection, Identification, and Occurrence of Thiotetronic Acids in Drinking Water from Underground Sources by Electrospray Ionization-High Field Asymmetric … jean pryorWebBiosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid–type III polyketide synthase M. Austin, Tamao Saito, M. Bowman, 2006, Nature chemical biology. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal ... jean prouve wikiWebJan 31, 2024 · The inhibitory potency against V. mali fatty acid synthase agreed well with the in vitro antifungal activity. The molecular docking suggested that the 3-acylthiotetronic … jean pruvost rcf